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The GABA-A subunit genes, the corresponding subunit name, and symbols:

 

GABRA1 (alpha-1 or α1)

GABRA2 (alpha-2, or α2)

GABRA3 (alpha 3, or α3)

GABRA4 (alpha 4, or α4)

GABRA5 (alpha-5, or α5)

GABRA6 (alpha-6, or α6)

 

GABRB1 (beta-1, or β1)

GABRB2 (beta-2, or β2)

GABRB3 (beta-3, or β3)

 

GABRG1 (gamma-1, or γ1)

GABRG2 (gamma-2, or γ2)

GABRG3 (gamma-3, or γ3)

 

GABRD (delta, or δ)

GABRE (epsilon, or ∈)

GABRP (pi, or π)

GABRQ (theta, or θ)

 

GABRR1 (rho-1)

GABRR2 (rho-2)

GABRR3 (rho-3)

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WHAT IS A GABA-A RECEPTOR?

GABA-A receptors are proteins on the cell surface of neurons.  GABA, the primary inhibitory neurotransmitter in the human brain, binds to and activates GABA-A receptors.  Genetic alterations in GABA-A receptor genes can cause changes to the protein which can cause disruptions in the brain’s balance of inhibition and excitation.

GABA-A receptors are made up of 5 subunits.  There are many possible subunit combinations that can exist in a GABA-A receptor. 

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