The GABA-A subunit genes, the corresponding subunit name, and symbols:
GABRA1 (alpha-1 or α1)
GABRA2 (alpha-2, or α2)
GABRA3 (alpha 3, or α3)
GABRA4 (alpha 4, or α4)
GABRA5 (alpha-5, or α5)
GABRA6 (alpha-6, or α6)
GABRB1 (beta-1, or β1)
GABRB2 (beta-2, or β2)
GABRB3 (beta-3, or β3)
GABRG1 (gamma-1, or γ1)
GABRG2 (gamma-2, or γ2)
GABRG3 (gamma-3, or γ3)
GABRD (delta, or δ)
GABRE (epsilon, or ∈)
GABRP (pi, or π)
GABRQ (theta, or θ)
GABRR1 (rho-1)
GABRR2 (rho-2)
GABRR3 (rho-3)
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WHAT IS A GABA-A RECEPTOR?
GABA-A receptors are proteins on the cell surface of neurons. GABA, the primary inhibitory neurotransmitter in the human brain, binds to and activates GABA-A receptors. Genetic alterations in GABA-A receptor genes can cause changes to the protein which can cause disruptions in the brain’s balance of inhibition and excitation.
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GABA-A receptors are made up of 5 subunits. There are many possible subunit combinations that can exist in a GABA-A receptor.
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